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SB 269970 hydrochloride

 - SB 269970A
Axon 2183
  • Parent CAS:  201038-74-6
  • Optical Purity:  Optically pure
  • Soluble in water and DMSO
  • MF:  C18H28N2O3S.HCl
  • MW:  388.95

Description

SB 269970 hydrochloride is a potent and selective serotonin 5-HT7 receptor antagonist with reported pKi of 8.9 for the 5-HT7a receptor and more than 50-fold selectivity over many serotonergic, dopaminergic and adrenergic receptors.

The 5-HT7 receptor regulates circadian rhythms, thermoregulation, mood, cognition and sensorimotor processing. SB 269970 is relevant for serotonergic CNS research and for studying antipsychotic-like effects in hyperactivity and prepulse-inhibition models.

Key Features

  • Potent 5-HT7 receptor antagonist
  • High selectivity over related monoamine receptors
  • Blocks 5-HT7a receptor signaling
  • Active in CNS behavioral pharmacology models

Applications

  • 5-HT7 receptor pharmacology
  • Serotonergic signaling studies
  • Schizophrenia model research
  • Circadian and cognitive pathway assays

More Information

Parent CAS No. 201038-74-6
Chemical Name (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidin-1-ylsulfonyl)phenol hydrochloride
SMILES C1(O)=CC=CC(S(N2CCC[C@@H]2CCN2CCC(C)CC2)(=O)=O)=C1.Cl |&1:11,r|
MFCD N.A.
InChi InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
InChiKey XQCJOYZLWFNDIO-PKLMIRHRSA-N
CID 11957684
Short Description 5-HT7 antagonist

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