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MRS 2578
Axon 1862
CAS:
711019-86-2
Purity:
99%
- Soluble in DMSO
- MF: C20H20N6S4
- MW: 472.67
Description
MRS 2578 is a potent and selective P2Y6 nucleotide receptor antagonist used to block UDP-responsive purinergic signaling.
P2Y6 is a Gq-coupled GPCR activated by uridine nucleotides and is implicated in inflammatory signaling, immune-cell activation, epithelial responses and microglial function. MRS 2578 is a useful tool for P2Y6 receptor pharmacology.
Key Features
- Selective P2Y6 receptor antagonist
- Blocks UDP-mediated nucleotide GPCR signaling
- Useful for purinergic inflammation research
- Supports analysis of calcium and inositol phosphate responses
Applications
- P2Y6 receptor functional assays
- Purinergic and nucleotide signaling studies
- Inflammatory cell and microglial response models
- GPCR antagonist profiling
More Information
| Parent CAS No. | 711019-86-2 |
|---|---|
| Chemical Name | 1,1'-(butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea) |
| SMILES | C(NCCCCNC(=S)NC1C=CC=C(C=1)N=C=S)(=S)NC1C=CC=C(C=1)N=C=S |
| MFCD | MFCD07370141 |
| InChi | InChI=1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30) |
| InChiKey | QOHNRGHTJPFMSL-UHFFFAOYSA-N |
| CID | 16078986 |
| Short Description | P2Y6 antagonist |
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