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NVP-BHG712
- BHG 712
Axon 1829
CAS:
940310-85-0
Purity:
98%
- Soluble in DMSO
- MF: C26H20F3N7O
- MW: 503.48
Description
NVP-BHG712 is a potent and specific EphB4 receptor tyrosine kinase inhibitor used to interrogate EphB4/ephrin-B2 signaling.
EphB4 signaling contributes to vascular development, angiogenesis, tumor vascularization and cell-positioning mechanisms. NVP-BHG712 is a useful tool for studying Eph receptor kinase activity and angiogenesis-associated signaling pathways.
Key Features
- Potent EphB4 kinase inhibitor
- Targets EphB4/ephrin-B2 signaling
- Relevant to vascular and angiogenesis biology
- Useful receptor tyrosine kinase pharmacology tool
Applications
- EphB4 kinase signaling studies
- Angiogenesis and vascular remodeling assays
- Tumor vascularization research
- Receptor tyrosine kinase phosphorylation analysis
More Information
| Parent CAS No. | 940310-85-0 |
|---|---|
| Chemical Name | 4-methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide |
| SMILES | C1(NC(=O)C2C=C(NC3N=C(C4C=NC=CC=4)N=C4N(C)N=CC=34)C(C)=CC=2)C=C(C(F)(F)F)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C26H20F3N7O/c1-15-8-9-16(25(37)32-19-7-3-6-18(12-19)26(27,28)29)11-21(15)33-23-20-14-31-36(2)24(20)35-22(34-23)17-5-4-10-30-13-17/h3-14H,1-2H3,(H,32,37)(H,33,34,35) |
| InChiKey | ZCCPLJOKGAACRT-UHFFFAOYSA-N |
| CID | 16747388 |
| Short Description | EphB4 inhibitor |
NVP-BHG712
potent EphB4 kinase inhibitor
BHG 712
BHG712
EphB4
EphB4 kinase
Inhibitor
EphB4 kinase signaling studies
Angiogenesis and vascular remodeling assays
Tumor vascularization research
Receptor tyrosine kinase phosphorylation analysis
angiogenesis
cancer biology
vascular biology
kinase signaling
signal transduction
receptor pharmacology
CAS 940310-85-0
Axon Medchem
Axon 1829
Supplier
Vendor
