Bulk Inquiry
DH 97
Axon 1351
CAS:
220339-00-4
Purity:
99%
- Soluble in DMSO
- MF: C22H26N2O
- MW: 334.45
Description
DH 97 is a selective melatonin MT2 receptor antagonist with reported Ki values of 252 nM at MT2 and 1.1 µM at MT1.
MT2 receptors contribute to circadian phase shifting, retinal signaling and sleep–wake regulation. DH 97 is used to define MT2-dependent responses and to differentiate MT2 from MT1 receptor pharmacology.
Key Features
- Selective antagonist of the melatonin MT2 receptor
- Reported Ki: 252 nM (MT2) and 1.1 µM (MT1)
- Useful for MT1 versus MT2 receptor discrimination
- Relevant to circadian and chronobiology studies
Applications
- MT2 receptor binding and functional assays
- Circadian rhythm and phase-shift research
- Melatonin receptor subtype profiling
- Retinal and sleep–wake signaling studies
More Information
| Parent CAS No. | 220339-00-4 |
|---|---|
| Chemical Name | Pentanoic acid [2-(2-benzyl-1H-indol-3-yl)-ethyl]-amide |
| SMILES | C1C=C2NC(CC3C=CC=CC=3)=C(CCNC(CCCC)=O)C2=CC=1 |
| MFCD | MFCD02262121 |
| InChi | InChI=1S/C22H26N2O/c1-2-3-13-22(25)23-15-14-19-18-11-7-8-12-20(18)24-21(19)16-17-9-5-4-6-10-17/h4-12,24H,2-3,13-16H2,1H3,(H,23,25) |
| InChiKey | HDOIPCLEKCEANF-UHFFFAOYSA-N |
| CID | 3467177 |
| Short Description | MT2 antagonist |
DH 97
selective antagonist of the melatonin MT2 receptor
DH97
DH-97
Melatonin
MT2
the melatonin MT2 receptor
Antagonist
MT2 receptor binding and functional assays
Circadian rhythm and phase-shift research
Melatonin receptor subtype profiling
Retinal and sleep–wake signaling studies
GPCR pharmacology
receptor selectivity
signal transduction
receptor pharmacology
CAS 220339-00-4
Axon Medchem
Axon 1351
Supplier
Vendor
References
- MT Teh & D Sugden. Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. N. S. Arch. Pharmacol. 1998, 358, 522.
- KN Ting et al. Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats. Br. J. Pharmacol. 1999, 127, 987.
Other Categories
Get a Quote for
Loading...