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SB 268262

Axon 1145
CAS:  217438-17-0
Purity:  99%
  • Soluble in DMSO
  • MF:  C18H15N3O4S2
  • MW:  401.46

Description

SB 268262 is a selective non-peptide CGRP1 receptor antagonist and the racemate related to the more active (+)-SB-273779 (Axon 4375). It is used to block calcitonin gene-related peptide receptor signaling.

CGRP signaling is involved in migraine biology, vasodilation, sensory neuron activation and neurogenic inflammation. SB 268262 is useful for CGRP receptor antagonist studies and comparison with enantiomerically enriched analogues.

Key Features

  • Selective non-peptide CGRP1 antagonist
  • Racemate related to (+)-SB-273779
  • Blocks CGRP receptor signaling
  • Useful for migraine and sensory neuron pathway research

Applications

  • CGRP receptor pharmacology
  • Migraine pathway studies
  • Neurogenic inflammation research
  • Vascular and sensory signaling assays

More Information

Parent CAS No. 217438-17-0
Chemical Name N-Methyl-3-nitro-4-(thiazole-2-sulfinyl)-N-o-tolyl-benzamide
SMILES C1(SC=CN=1)S(=O)C1C([N+]([O-])=O)=CC(C(N(C)C2C(C)=CC=CC=2)=O)=CC=1
MFCD MFCD10565932
InChi InChI=1S/C18H15N3O4S2/c1-12-5-3-4-6-14(12)20(2)17(22)13-7-8-16(15(11-13)21(23)24)27(25)18-19-9-10-26-18/h3-11H,1-2H3
InChiKey YXHLPJQQPOMPGE-UHFFFAOYSA-N
CID 6918567
Short Description CGRP1 antagonist

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