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Axon 2551
CAS [349438-38-6]
MF C15H11Cl2NO3MW 324.16
Small molecule activator of ALDH2 (EC50 value ca 6 μM for ALDH2 mediated acetaldehyde metabolism) with the ability to activate wild-type ALDH2 and restore near-wild-type activity to ALDH2*2. When administered to rats before an ischemic event, Alda 1 reduced infarct size by 60%, most likely through its inhibitory effect on the formation of cytotoxic aldehydes. Alda-1 was effective in protecting against rotenone-induced apoptotic cell death in both SH-SY5Y cells and primary cultured substantia nigra (SN) dopaminergic neurons, and significantly reduced rotenone- or MPTP-induced death of SN tyrosine hydroxylase (TH)-positive dopaminergic neurons.
KEYWORDS: Alda 1 | supplier | ALDH2 activator | Alda1 | CAS [349438-38-6] | Alcohol | ALDH | Activator | agonist | ALDH2*2 | dehydrogenase | alcoholism | ischemia | chaperone | neuroprotective | dopamine neurons | rotenone | MPTP | substantia nigra
N-(benzo[d][1,3]dioxol-5-ylmethyl)-2,6-dichlorobenzamide
[349438-38-6]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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