Linagliptin - BI 1356

Based on 696 publications in PubMed 10 10 696

Axon 2354

CAS [668270-12-0]

MF C25H28N8O2
MW 472.54

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

Linagliptin

Description

Competitive and highly selective dipeptidyl peptidase (DPP)-4 inhibitor (IC50 value ca. 1 nM in vitro) with superior potency and long duration of action in vivo. Linagliptin is ≥10,000-fold more selective for DPP-4 than DPP-8, DPP-9, amino-peptidases N and P, prolyloligopeptidase, trypsin, plasmin, and thrombin and is 90-fold more selective than for fibroblast activation protein in vitro. Approved drug for treatment of type 2 diabetes with long-lasting effects on glucose tolerance through control of GLP-1 and insulin.

J. Rungby. Inhibition of dipeptidyl peptidase 4 by BI-1356, a new drug for the treatment of beta-cell failure in type 2 diabetes. Exp.Opin. Investig. Drugs. 2009, 18, 835-838.

L. Thomas et al. (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor,…. J. Pharmacol. Exp. Ther. 2008, 325, 175-182.

Competitive and highly selective dipeptidyl peptidase (DPP)-4 inhibitor

Chemical name

(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-ynyl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione

Parent CAS No.

[668270-12-0]

Order

Size	Unit Price	Stock
10 mg	€90.00	In Stock
50 mg	€270.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1228	Butabindide oxalate	TPP2 inhibitor	€105.00
1631	Vildagliptin	DPP4 inhibitor	€60.00
2470	Trelagliptin succinate	Orally active DPP4 inhibitor for the treatment of type 2 diabetes	€145.00
2434	1-Deazaadenosine	Adenosine deaminase (ADA) inhibitor with cytostatic activity in vitro	€140.00
3251	Sitagliptin	Potent, selective and orally active DPP-4 inhibitor	€50.00
3310	Alogliptin benzoate	Potent, highly selective and orally active DPP-4 inhibitor	€65.00
3309	Teneligliptin hydrobromide	Highly potent, selective, long-lasting and orally active DPP-4 inhibitor	€50.00
2766	AZD7986	Potent, reversible, and selective DPP1 inhibitor	€140.00
3438	NDMC101	DPP-4 inhibitor; Osteoclastogenesis inhibitor	€90.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

Linagliptin - BI 1356

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

Linagliptin - BI 1356

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us