PD90780

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2174

CAS [77422-99-2]

MF C19H14N4O4
MW 362.34

Purity: 99%
Soluble in DMSO

PD90780

Description

A nonpeptide inhibitor of nerve growth factor's binding to the P75 NGF receptor; It binds to NGF, not to the P75 receptor. Differential activity of PD90780 suggests altered NGF-p75NTR interactions in the presence of TrkA.

K Spiegel et al. PD 90780, a nonpeptide inhibitor of nerve growth factor's binding to the P75 NGF receptor. Biochem. Biophys. Res. Comm. 1995, 217, 488-494.

A Colquhoun et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered (...). J. Pharm. Exp. Ther. 2004, 310, 505-511.

Apoptosis Cell Signaling & Oncology p75 NTR NF-κB MAPK JAK-STAT PI3K-Akt-mTOR RTK class VII; EC 2.7.10.1

Inhibitor of NGFs binding to the P75 NGFR

Chemical name

7-benzamido-4-methyl-9-oxo-4,9-dihydropyrazolo[5,1-b]quinazoline-2-carboxylic acid

Parent CAS No.

[77422-99-2]

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5 mg	€110.00	In Stock
25 mg	€380.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€160.00	In Stock
2 x 25 mg	€600.00	In Stock

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PD90780

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