GPR27
SREB (Super Conserved Receptor Expressed in Brain), consists of at least three members, termed SREB1, SREB2, and SREB3. These share many features common to GPCR proteins, including seven hydrophobic TM domains, potential N-linked glycosylation sites in the amino terminal extracellular domain, and cysteines in the first and second extracellular loop which may form a disulfide bridge. The high sequence conservation and abundant expression in the central nervous system suggest the existence of undiscovered fundamental neuronal systems consisting of SREB family members and their endogenous ligand(s)[1].
To date, no endogenous ligand has been described for GPR27, but it has been suggested that it is involved in insulin promoter activity and secretion. The precise signalling events linking GPR27 and its effects on insulin are still elusive, and its function in the central nervous system remains unknown[2].
[1] M Matsumoto et al. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochem Biophys Res Commun. 2000 Jun 7;272(2):576-82.
[2] N Dupuis et al. Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment. Mol Pharmacol. 2017 Jun;91(6):595-608.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2915 | CID 1375606 | Analog of CID 5157334 | €95.00 | |
| 3926 | CID 5157334 | Selective surrogate agonist for GPR27 | €95.00 | |