CLRN
The vertebrate-specific clarin (CLRN) protein family is characterized by four transmembrane-domains, conserved sequence motifs and a single glycosylation consensus site between TM1 and TM2[1].A mutation in the clarin-1 gene is related to Usher syndrome 3A, which is an autosomal recessive disorder, characterized by progressive loss of hearing and vision[2].
[1] A Adato et al. USH3A transcripts encode clarin-1, a four-transmembrane-domain protein with a possible role in sensory synapses. Eur J Hum Genet. 2002 Jun;10(6):339-50.
[2] R Geng et al. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet. 2009 Aug 1;18(15):2748-60.