Cytosolic Phosphoenolpyruvate carboxykinase (cPEPCK; EC 126.96.36.199) is an enzyme in the lyase family used in the metabolic pathway of gluconeogenesis. It converts oxaloacetate into phosphoenolpyruvate and carbon dioxide. cPEPCK has become a virtual marker for hepatic gluconeogenesis, and the level of its gene transcription in the liver is considered an important indicator in the evaluation of type 2 diabetes.
 A Perspective on the Biology of Phosphoenolpyruvate Carboxykinase 55 Years After Its Discovery. R.W. Hanson. J. Biol. Chem.Them. Minirev. Ser. 2009, 1-6.