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TMDJ-035

Name: TMDJ-035
SKU: 4111

- Ryanozole

Axon 4111

CAS: 2681302-83-8

Purity: 99%

Soluble in DMSO

MF: C16H12F3N5O
MW: 347.29

Description

TMDJ-035 is a first highly potent and selective RyR2 inhibitor with an EC50 value of 0.013 μM. TMDJ-035 suppressed abnormal Ca2+ waves and transients in cardiomyocytes from a mouse model with RyR2(R420W) mutation. The inactive analog TMDJ-011 is available as Axon 4213.

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Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

Parent CAS No.	2681302-83-8
Chemical Name	2-(5-(3,5-Difluorophenyl)-2H-tetrazol-2-yl)-N-(4-fluorophenyl)-N-methylacetamide
MFCD	N.A.
Short Description	RyR2 inhibitor

TMDJ-035 RyR2 inhibitor TMDJ035 TMDJ 035 CAS 2681302-83-8 Axon Medchem Axon 4111 Calcium RyR Inhibitor Ion Channels Cardiac arrhythmia Muscle contraction CPVT ARVC Supplier Vendor

References

R Ishida et al. A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. Eur J Med Chem. 2023 Dec 15;262:115910.

Related Products

AXON ID	NAME	DESCRIPTION	FROM PRICE
4213	TMDJ-011	Inactive analogue of TMDJ-035	From $132.00

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TMDJ-035

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