Emraclidine - CVL231

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 4086

CAS [2170722-84-4]

MF C20H21F3N4O
MW 390.40

Purity: 99%
Soluble in 0.1N HCl(aq), DMSO and EtOH

Emraclidine

Description

Emraclidine is a brain-penetrant, highly selective M4 receptor positive allosteric modulator.

Keywords: Emraclidine | Supplier | PAM of M4 mAChR | CVL231 | CVL 231 | CVL-231 | CAS [2170722-84-4] | Acetylcholine | CHRM4 | PAM | Receptors | Schizophrenia

JH Krystal et al. Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial. Lancet. 2022 Dec 17;400(10369):2210-2220.

CNS CHRM4 A18

Highly selective, brain-penetrant PAM of M4 mAChR

Chemical name

1-(2,4-Dimethyl-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-2-(1-(2-(trifluoromethyl)pyridin-4-yl)azetidin-3-yl)ethanone

Parent CAS No.

[2170722-84-4]

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5 mg	€140.00	In Stock
25 mg	€560.00	In Stock

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