PDS0330 is a potent and selective first-generation claudin-1 inhibitor. PDS0330 inhibits claudin-1-dependent CRC progression without exhibiting toxicity in in-vitro and in-vivo models of CRC and it binds directly and specifically to claudin-1 with micromolar affinity.

KEYWORDS: PDS0330 | Supplier | Claudin-1 inhibitor | KVA-E-23A | PDS 0330 | PDS-0330 | CAS [2904682-19-3] | Non Selective | Claudin | Inhibitor | Proteins | Colon cancer | CRC | Src and β-catenin-signaling | CLDN1