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Axon 3826
CAS [2348493-39-8]
MF C26H29N6O7PMW 568.52
The ProTide NUC-7738 is a phosphoramidate prodrug of Cordycepin (3’-dA, Axon 3825) and showed potent cytotoxic activity against a panel of hematological cancer cell lines. Moreover, NUC-7738 was able to bypass the premature breakdown, the poor uptake, and the kinase dependence for phosphorylation of the parental nucleoside. NUC-7738 promotes proapoptotic pathways and attenuates NF-kB.
KEYWORDS: NUC-7738 | Supplier | Anticancer agent | 3’-Deoxyadenosine 5’-O-phenyl-(benzoxy-L-alaninyl)-phosphate | NUC 7738 | NUC7738 | CAS [2348493-39-8] | Adenosine | Non Selective | Inhibitor | Advanced solid tumor | Lymphoma | ProTide | Prodrug
(2S)-Benzyl 2-((((2S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
[2348493-39-8]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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