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Lac-Phe - N-lactoyl-phenylalanine | N-lactoyl-Phe

Based on 9 reference(s) in Google Scholar 8 10 9

Axon 3776

CAS [183241-73-8]

MF C12H15NO4
MW 237.25

Purity: 99%
Optical purity: Optically pure
Soluble in water, DMSO and EtOH

Lac-Phe

Description

Lac-Phe is an exercise-inducible metabolite that suppresses feeding and obesity.

KEYWORDS: Lac-Phe | Supplier | Metabolite | N-lactoyl-phenylalanine | N-lactoyl-Phe | CAS [183241-73-8] | L-Lactate | L-Phenylalanine | Obesity | Type 2 diabetes | Cardiometabolic disease

VL Li et al. An exercise-inducible metabolite that suppresses feeding and obesity. Nature. 2022 Jun;606(7915):785-790.

RS Jansen et al. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601-6.

S Xiao et al. Lac-Phe mediates the effects of metformin on food intake and body weight. Nat Metab. 2024 Mar 18.

B Scott et al. Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans. Nat Metab. 2024 Mar 18.

Cardiovascular Diabetes & Metabolism

Blood-borne signaling metabolite; Suppressor of feeding and obesity

Chemical name

(S)-2-((S)-2-Hydroxypropanamido)-3-phenylpropanoic acid

Parent CAS No.

[183241-73-8]

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