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Apararenone - MT3995

Based on 13 reference(s) in Google Scholar 8 10 13

Axon 3742

CAS [945966-46-1]

MF C17H17FN2O4S
MW 364.39

  • Purity: 99%
  • Soluble in DMSO

Apararenone

Description

Apararenone is a potent and highly selective nonsteroidal mineralocorticoid receptor (MR) antagonist (Ki value of 0.104 μM). Apararenone exhibited a more potent antihypertensive and organ-protective activity than steroidal MRA eplerenone in a primary aldosteronism rat model obtained by infusing aldosterone in uninephrectomized rats.

KEYWORDS: Apararenone | Supplier | MR antagonist | MT3995 | MT 3995 | MT-3995 | CAS [945966-46-1] | Mineralocorticoid | Mineralocorticoid (MR) | Antagonist | Receptors | Hypertension | Kidney disease | Heart failure

Potent and highly selective nonsteroidal mineralocorticoid receptor (MR) antagonist

Chemical name

N-(4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide

Parent CAS No.

[945966-46-1]

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10 mg €130.00 In Stock
50 mg €520.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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