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L6H21
- MD-2 inhibitor L6H21
Axon 3683
CAS:
24533-47-9
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C18H18O4
- MW: 298.33
Description
L6H21 is a specific MD-2 inhibitor and directly binds to MD-2 protein (Kd value of 33.3 μM), blocking the formation of the LPS-TLR4/MD-2 complex.
More Information
| Parent CAS No. | 24533-47-9 |
|---|---|
| Chemical Name | (E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one |
| SMILES | C1C=C(C(=O)/C=C/C2C(OC)=C(OC)C=CC=2)C=CC=1OC |
| MFCD | N.A. |
| InChi | InChI=1S/C18H18O4/c1-20-15-10-7-13(8-11-15)16(19)12-9-14-5-4-6-17(21-2)18(14)22-3/h4-12H,1-3H3/b12-9+ |
| InChiKey | IECVLMVZGCYCSZ-FMIVXFBMSA-N |
| CID | 5346378 |
| Short Description | MD-2 inhibitor |
References
- J Wu et al. Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents. J Med Chem. 2011 Dec 8;54(23):8110-23.
- Y Wang et al. MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br J Pharmacol. 2015 Sep;172(17):4391-405.
