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L6H21 - MD-2 inhibitor L6H21

Based on 17 reference(s) in Google Scholar 8 10 17

Axon 3683

CAS [24533-47-9]

MF C18H18O4
MW 298.33

Purity: 99%
Soluble in DMSO and EtOH

L6H21

Description

L6H21 is a specific MD-2 inhibitor and directly binds to MD-2 protein (Kd value of 33.3 μM), blocking the formation of the LPS-TLR4/MD-2 complex.

KEYWORDS: L6H21 | Supplier | MD-2 inhibitor | MD-2 inhibitor L6H21 | CAS [24533-47-9] | [18778-38-6] | DNA-RNA | TLR | Inhibitor | Receptors | Anti-sepsis | Inflammation | Myeloid differentiation 2

J Wu et al. Evaluation and discovery of novel synthetic chalcone derivatives as anti-inflammatory agents. J Med Chem. 2011 Dec 8;54(23):8110-23.

Y Wang et al. MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br J Pharmacol. 2015 Sep;172(17):4391-405.

Immunology Pain & Inflammation NF-κB MAPK Toll-like Receptors TLR

Specific MD-2 inhibitor

Chemical name

(E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one

Parent CAS No.

[24533-47-9]

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Size	Unit Price	Stock
10 mg	€120.00	In Stock
50 mg	€420.00	In Stock

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