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ABR-238901
Axon 3631
CAS:
1638200-22-2
Purity:
98%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C11H9BrClN3O4S
- MW: 394.63
Description
ABR-238901 is a S100A8/A9 blocker that potently inhibits S100A8/A9 interaction with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4 (toll-like receptor 4).
More Information
| Parent CAS No. | 1638200-22-2 |
|---|---|
| Chemical Name | 5-Bromo-N-(5-chloro-4-hydroxypyridin-3-yl)-6-methoxypyridine-3-sulfonamide |
| SMILES | C1(OC)N=CC(S(=O)(=O)NC2C(O)=C(Cl)C=NC=2)=CC=1Br |
| MFCD | N.A. |
| InChi | InChI=1S/C11H9BrClN3O4S/c1-20-11-7(12)2-6(3-15-11)21(18,19)16-9-5-14-4-8(13)10(9)17/h2-5,16H,1H3,(H,14,17) |
| InChiKey | IXVPHMAWVYMOQL-UHFFFAOYSA-N |
| CID | 86280668 |
| Short Description | S100A9 blocker |
References
- K De Veirman et al. Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion. Cancer Immunol Res. 2017 Oct;5(10):839-846.
- G Marinković et al. S100A9 Links Inflammation and Repair in Myocardial Infarction. Circ Res. 2020 Aug 14;127(5):664-676.
- A Schiopu et al. P4026 Short-term blockade of the S100A8/A9 alarmin in the immediate post-myocardial infarction period inhibits acute myocardial inflammation and preserves myocardial repair, European Heart Journal, Volume 38, Issue suppl_1, August 2017, ehx504.P4026.
