Fludarabine, a nucleoside analogue, inhibits DNA synthesis in proliferating cells; however, in indolent cells fludarabine has an inhibitory effect on RNA transcription. Additionally, Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation.

KEYWORDS: Fludarabine | Supplier | DNA synthesis inhibitor | 9-β-D-Arabinofuranosyl-2-fluoroadenine | F-ara-A | CAS [21679-14-1] | DNA-RNA | STAT1 | Inhibitor | Transcription Factors | B-cell lymphocytic leukemia | Hairy cell leukaemia | Indolent lymphoma | Multiple myeloma