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K22
- ZIKV inhibitor K22
Axon 3432
CAS:
2141978-86-9
Purity:
98%
- Soluble in DMSO
- MF: C27H25BrN2O3
- MW: 505.4
Description
K22 is an inhibitor of coronavirus replication that specifically interferes with membrane-bound coronaviral RNA synthesis (IC50 value of 0.7 µM for HCoV-229E plaques). K22 displayed antiviral activity against a broad range of animal and human coronaviruses, including MERS-CoV.
More Information
| Parent CAS No. | 2141978-86-9 |
|---|---|
| Chemical Name | (Z)-N-(3-(4-(4-Bromophenyl)-4-hydroxypiperidin-1-yl)-3-oxo-1-phenylprop-1-en-2-yl)benzamide |
| SMILES | C1(Br)C=CC(C2(O)CCN(C(=O)/C(=C/C3C=CC=CC=3)/NC(=O)C3C=CC=CC=3)CC2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C27H25BrN2O3/c28-23-13-11-22(12-14-23)27(33)15-17-30(18-16-27)26(32)24(19-20-7-3-1-4-8-20)29-25(31)21-9-5-2-6-10-21/h1-14,19,33H,15-18H2,(H,29,31)/b24-19- |
| InChiKey | CMBUSPXASRNJHI-CLCOLTQESA-N |
| CID | 5433970 |
| Short Description | Coronavirus inhibitor |
References
- A Lundin et al. Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus. PLoS Pathog. 2014 May 29;10(5):e1004166.
- O García-Nicolás et al. The Small-Compound Inhibitor K22 Displays Broad Antiviral Activity against Different Members of the Family Flaviviridae and Offers Potential as a Panviral Inhibitor. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01206-18.
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