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TCPOBOP
Axon 3411
CAS:
76150-91-9
Purity:
99%
- Soluble in DMSO
- MF: C16H8Cl4N2O2
- MW: 402.06
Description
TCPOBOP is a constitutive androstane receptor (CAR) agonist with an EC50 value of 20 nM. TCPOBOP is also a highly potent phenobarbital-like inducer of CYP gene expression.
More Information
| Parent CAS No. | 76150-91-9 |
|---|---|
| Chemical Name | 1,4-Bis(3,5-dichloropyridin-2-yloxy)benzene |
| SMILES | C1C(OC2N=CC(Cl)=CC=2Cl)=CC=C(OC2C(Cl)=CC(Cl)=CN=2)C=1 |
| MFCD | MFCD00057368 |
| InChi | InChI=1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H |
| InChiKey | BAFKRPOFIYPKBQ-UHFFFAOYSA-N |
| CID | 5382 |
| Short Description | CAR agonist |
References
- ES Baskin-Bey et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.
- I Tzameli et al. The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol Cell Biol. 2000 May;20(9):2951-8.
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