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Sardomozide dihydrochloride
- CGP48664A - CGP48664 dihydrochloride
Axon 3290
- Parent CAS: 149400-88-4
Purity:
98%
- Soluble in water and DMSO
- MF: C11H14N6.2HCl
- MW: 303.19
Description
Sardomozide dihydrochloride is a potent and selective inhibitor of S-Adenosylmethionine decarboxylase (SAMDC) with an IC50 value of 5 nM.
More Information
| Parent CAS No. | 149400-88-4 |
|---|---|
| Chemical Name | 2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide dihydrochloride |
| SMILES | Cl.Cl.C1(C(=N)N)C2CC/C(=NNC(N)=N)/C=2C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C11H14N6.2ClH/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15;;/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17);2*1H/b16-9+;; |
| InChiKey | UHEIPGJSFDAPIC-NENXIMLWSA-N |
| CID | 10402702 |
| Short Description | SAMDC inhibitor |
References
- J Stanek et al. 4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase. J Med Chem. 1993;36(15):2168-2171.
- U Regenass et al. CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity. Cancer Res. 1994 Jun 15;54(12):3210-7.
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