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JHU37160
Axon 3281
CAS:
2369979-68-8
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C19H20ClFN4
- MW: 358.84
Description
JHU37160 is a potent DREADD agonist with hM3Dq and hM4Di Ki values of 1.9 nM and 3.6 nM, respectively; and with hM3Dq and hM4Di EC50 values of 18.5 nM and 0.2 nM, respectively. JHU37160 is a first DREADD agonist with high in vivo potency for CNS applications.
More Information
| Parent CAS No. | 2369979-68-8 |
|---|---|
| Chemical Name | 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine |
| SMILES | N1C2C=C(Cl)C=CC=2NC2C(F)=CC=CC=2C=1N1CCN(CC)CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-14-4-3-5-15(21)18(14)22-16-7-6-13(20)12-17(16)23-19/h3-7,12,22H,2,8-11H2,1H3 |
| InChiKey | SWSCWOSASZXIRK-UHFFFAOYSA-N |
| CID | 139033723 |
| Short Description | DREADD agonist |
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