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Cytarabine
- 1-β-D-Arabinofuranosylcytosine - Ara-C - Cytosine arabinoside
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C9H13N3O5
- MW: 243.22
Description
Cytarabine is a cytidine-based antimetabolite and an inhibitor of DNA synthesis. Cytarabine undergoes initial phosphorylation by deoxycytidine kinase to monophosphate with subsequent phosphorylations catalyzed by pyrimidine monophosphate and diphosphate kinases. The active form, triphosphorylated Cytarabine, exhibits its anticancer activity via the inhibition of DNA polymerase and/or DNA chain elongation.
More Information
| Parent CAS No. | 147-94-4 |
|---|---|
| Chemical Name | 4-Amino-1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one |
| SMILES | O1[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1N1C=CC(N)=NC1=O |&1:1,4,6,8,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1 |
| InChiKey | UHDGCWIWMRVCDJ-CCXZUQQUSA-N |
| CID | 6253 |
| Short Description | DNA synthesis inhibitor |
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