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NIBR189
Axon 3231
CAS:
1599432-08-2
Purity:
99%
- Soluble in DMSO
- MF: C21H21BrN2O3
- MW: 429.31
Description
NIBR189 is a potent and selective antagonist of the oxysterol receptor EBI2/GPR183, with IC50 values of 11 nM for human EBI2 and 15 nM for mouse EBI2. NIBR189 blocks receptor activation by endogenous oxysterol ligands and inhibits EBI2-driven migration.
NIBR189 is used to examine EBI2 pharmacology across human and mouse systems, receptor-guided immune-cell positioning and oxysterol-dependent chemotaxis. Its cross-species potency and useful pharmacokinetic properties make it suitable for translating cell-based findings into in vivo immune and inflammatory models.
Key Features
- Selective EBI2/GPR183 antagonist
- IC50: 11 nM at human EBI2
- IC50: 15 nM at mouse EBI2
- Blocks oxysterol-driven receptor signaling and chemotaxis
Applications
- EBI2 receptor pharmacology
- Oxysterol signaling studies
- Immune-cell migration assays
- Cross-species in vivo research
More Information
| Parent CAS No. | 1599432-08-2 |
|---|---|
| Chemical Name | (E)-3-(4-Bromophenyl)-1-(4-(4-methoxybenzoyl)piperazin-1-yl)prop-2-en-1-one |
| SMILES | C1C=C(/C=C/C(N2CCN(C(C3C=CC(OC)=CC=3)=O)CC2)=O)C=CC=1Br |
| MFCD | N.A. |
| InChi | InChI=1S/C21H21BrN2O3/c1-27-19-9-5-17(6-10-19)21(26)24-14-12-23(13-15-24)20(25)11-4-16-2-7-18(22)8-3-16/h2-11H,12-15H2,1H3/b11-4+ |
| InChiKey | OFHXXBRBGWUOHR-NYYWCZLTSA-N |
| CID | 36295259 |
| Short Description | EBI-2 antagonist |
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