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ML 239
- DEV 4 - CID 49843203
Axon 2871
CAS:
1378872-36-6
Purity:
98%
- Soluble in DMSO
- MF: C13H10Cl3N3O2
- MW: 346.6
Description
ML 239 is a selective inhibitor of breast cancer stem cells (IC50 value of 1.16 µM). Displayed greater than 23-fold selective inhibition of the breast cancer stem cells-like cell line over the isogenic control cell line.
More Information
| Parent CAS No. | 1378872-36-6 |
|---|---|
| Chemical Name | (E)-N'-((1H-Pyrrol-2-yl)methylene)-2-(2,4,6-trichlorophenoxy)acetohydrazide |
| SMILES | C1C(Cl)=C(OCC(=O)N/N=C/C2=CC=CN2)C(Cl)=CC=1Cl |
| MFCD | MFCD23098913 |
| InChi | InChI=1S/C13H10Cl3N3O2/c14-8-4-10(15)13(11(16)5-8)21-7-12(20)19-18-6-9-2-1-3-17-9/h1-6,17H,7H2,(H,19,20)/b18-6+ |
| InChiKey | NVEDPFICKAIHKD-NGYBGAFCSA-N |
| CID | 135999136 |
| Short Description | BCSC inhibitor |
References
- L Carmody et al. Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 1. Probe Reports from the NIH Molecular Libraries Program. 2010-2011.
- AR Germain et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorg Med Chem Lett. 2012 May 15;22(10):3571-4.
