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FPS-ZM1
Axon 2858
CAS:
945714-67-0
Purity:
99%
- Soluble in DMSO
- MF: C20H22ClNO
- MW: 327.85
Description
FPS-ZM1 is a high-affinity RAGE-specific inhibitor (Ki value of 25 nM) which binds specifically to the V domain of RAGE, crosses the BBB, and inhibits Aβ-induced cellular stress in RAGE-expressing cells in vitro and in brain in vivo. FPS-ZM1 was not toxic to cells and mice.
More Information
| Parent CAS No. | 945714-67-0 |
|---|---|
| Chemical Name | N-Benzyl-4-chloro-N-cyclohexylbenzamide |
| SMILES | C1C=C(CN(C2CCCCC2)C(=O)C2C=CC(Cl)=CC=2)C=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H22ClNO/c21-18-13-11-17(12-14-18)20(23)22(19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2 |
| InChiKey | XDFKWGIBQMHSOH-UHFFFAOYSA-N |
| CID | 24752728 |
| Short Description | RAGE inhibitor |
