SPA70 - LC-1 | Specific PXR antagonist 70

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2807

CAS [931314-31-7 ]

MF C21H25N3O4S
MW 415.51

  • Purity: 99%
  • Soluble in DMSO
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SPA70

Description

SPA70 is a potent and selective human pregnane X receptor (hPXR) antagonist with IC50 values of 510 nM (cell-based hPXR antagonistic assay) and 540 nM (cell-free competitive hPXR TR-FRET-binding assay). SPA70 inhibits hPXR in human hepatocytes and humanized mouse models and enhances the chemosensitivity of cancer cells, consistent with the role of hPXR in drug resistance.

KEYWORDS: SPA70 | supplier | hPXR antagonist | LC-1  | Specific PXR antagonist 70 | SPA 70 | SPA-70 | LC 1  | LC1  | CAS [931314-31-7] | Metabolism | PXR | Antagonist | Receptors | Cancer | Hepatocyte

Potent and selective human pregnane X receptor (hPXR) antagonist

Chemical name

4-(4-tert-Butylphenylsulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole

Parent CAS No.

[931314-31-7 ]

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5 mg €125.00 In Stock
25 mg €425.00 In Stock
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2 x 5 mg €200.00 In Stock
2 x 25 mg €680.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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