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SPA70
- LC-1 - Specific PXR antagonist 70
Axon 2807
CAS:
931314-31-7
Purity:
99%
- Soluble in DMSO
- MF: C21H25N3O4S
- MW: 415.51
Description
SPA70 is a potent and selective human pregnane X receptor (hPXR) antagonist with IC50 values of 510 nM (cell-based hPXR antagonistic assay) and 540 nM (cell-free competitive hPXR TR-FRET-binding assay). SPA70 inhibits hPXR in human hepatocytes and humanized mouse models and enhances the chemosensitivity of cancer cells, consistent with the role of hPXR in drug resistance.
More Information
| Parent CAS No. | 931314-31-7 |
|---|---|
| Chemical Name | 4-(4-tert-Butylphenylsulfonyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole |
| SMILES | C1C(OC)=CC(N2C(C)=C(S(=O)(=O)C3C=CC(C(C)(C)C)=CC=3)N=N2)=C(OC)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H25N3O4S/c1-14-20(29(25,26)17-10-7-15(8-11-17)21(2,3)4)22-23-24(14)18-13-16(27-5)9-12-19(18)28-6/h7-13H,1-6H3 |
| InChiKey | OIOPHIFJQXHPAF-UHFFFAOYSA-N |
| CID | 20865737 |
| Short Description | hPXR antagonist |
