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Axon 2774
CAS [356568-70-2]
MF C19H15N3OSMW 333.41
Selective β-arrestin/β2-adaptin interaction inhibitor (IC50 values of 19.1 and 15.6 μM for β-arrestin1 and β-arrestin2, respectively). Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors, but does not affect β-arrestin-independent (transferrin) or AP2-independent (endothelin-A) receptor internalization.
KEYWORDS: Barbadin | supplier | β-Arrestin/β2-Adaptin inhibitor | CAS [356568-70-2] | AP2 | β-Arrestin | Inhibitor | Proteins | GPCR | β2-Adrenergic | V2-Vasopressin | Angiotensin-II type-1 | Transferrin | Endothelin-A
3-Amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one
[356568-70-2]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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