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BAM15

Axon 2736
CAS:  210302-17-3
Purity:  99%
  • Soluble in DMSO
  • MF:  C16H10F2N6O
  • MW:  340.29

Description

BAM15 is a mitochondrial protonophore that functions as a mitochondrial oxidative-phosphorylation uncoupler without directly depolarizing the plasma membrane. It dissipates the mitochondrial proton gradient, increasing oxygen consumption and substrate oxidation while decreasing coupling efficiency and ATP production.

Compared with FCCP, BAM15 can support a higher maximal respiratory rate and shows a wider experimental window in several cell systems. It is used to investigate mitochondrial bioenergetics, nutrient oxidation, metabolic adaptation and ischemia–reperfusion injury, and has shown in vivo activity in models of obesity and insulin resistance.

Key Features

  • Mitochondrial protonophore uncoupler
  • Does not directly depolarize the plasma membrane
  • Increases maximal mitochondrial respiration
  • Bioactive in metabolic and renal-injury models

Applications

  • Mitochondrial respiration assays
  • Oxidative phosphorylation research
  • Energy-expenditure and nutrient-oxidation studies
  • Obesity and insulin-resistance models
  • Ischemia–reperfusion research

More Information

Parent CAS No. 210302-17-3
Chemical Name N5,N6-Bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
SMILES N1=C(NC2C(F)=CC=CC=2)C(NC2C=CC=CC=2F)=NC2=NON=C12
MFCD MFCD00373912
InChi InChI=1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24)
InChiKey OEGJBRZAJRPPHL-UHFFFAOYSA-N
CID 565708
Short Description Mitochondrial uncoupler

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