The CIP2A inhibitor TD52 had more potent apoptotic effects than erlotinib (Axon 1128) in HCC cells (IC50 values of 0.9, 0.9, 0.8 and 1.2 μM in HA22T, Hep3B, PLC5 and Sk-Hep1 cell lines, respectively). Also, CIP2A-dependent p-Akt downregulation mediates TD52-induced apoptosis in TNBC. TD52-induced tumor inhibition was associated with reactivation of PP2A and downregulation of CIP2A and p-Akt in vivo.

KEYWORDS: TD52 | supplier | CIP2A inhibitor | TD 52 | TD-52 | CAS [1798328-24-1] | PP2A | CIP2A | Inhibitor | Proteins | p90 | KIAA1524 | HCC | TNBC