PTC 209

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2420

CAS [315704-66-6]

MF C17H13Br2N5OS
MW 495.19

  • Purity: 99%
  • Soluble in DMSO

PTC 209


Inhibitor of the canonical self-renewal regulator BMI-1, a vital part of the polycomb repressive complex 1 (PRC1; IC50 value 0.5 µM for inhibition of UTR-mediated luciferase BMI-1 reporter expression). Treatment of primary colorectal cancer xenografts with PTC209 resulted in colorectal CIC loss with long-term and irreversible impairment of tumor growth. PTC-209 preferentially inhibits the proliferation of human lymphoma U937 and HT1080 tumor cells, and is less effective in primary human peripheral blood mononuclear cells and human hematopoietic stem cells.
Size Unit Price Stock
10 mg €125.00 In Stock
50 mg €475.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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