Eltrombopag - SB 497115

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1872

CAS [496775-61-2]

MF C25H22N4O4
MW 442.47

Purity: 98%
Soluble in 0.1N NaOH(aq) and DMSO

Eltrombopag

Description

First-in-class, oral, nonpeptide thrombopoietin receptor (TpoR or MPL) agonist, which is developed as a treatment for thrombocytopenia of various etiologies. Eltrombopag activates TpoR signaling pathway and induces proliferation and differentiation in mammalian cells and cell lines

JM Jenkins et al. Phase 1 clinical study of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist. Blood 2007, 109 (11), 4739–4741.

JB Bussel et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N. Engl. J. Med. 2007, 357(22), 2237-2247.

CL Erickson‐Miller et al. Preclinical Activity of Eltrombopag (SB‐497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist. Stem Cells 2009, 27(2), 424-430.

Thrombopoietin receptor (TpoR or c-MPL) agonist

Chemical name

(Z)-3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxybiphenyl-3-carboxylic acid

Parent CAS No.

[496775-61-2]

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Eltrombopag - SB 497115

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