Pyridomycin
Axon N0070
CAS:
18791-21-4
Purity:
90%
- Soluble in DMSO
- MF: C27H32N4O8
- MW: 540.57
Description
Antimycobacterial, enoyl-ACP reductase inhibitor; Source:Streptomyces sp.
More Information
| Parent CAS No. | 18791-21-4 |
|---|---|
| Chemical Name | N-[(2Z,5R,6S,9S,10S,11R)-2-butan-2-ylidene-10-hydroxy-5,11-dimethyl-3,7,12-trioxo-9-(pyridin-3-ylmethyl)-1,4-dioxa-8-azacyclododec-6-yl]-3-hydroxypyridine-2-carboxamide |
| SMILES | C1(=O)[C@@H](NC(=O)C2N=CC=CC=2O)[C@@H](C)OC(=O)/C(=C(/CC)C)/OC(=O)[C@H](C)[C@H](O)[C@H](CC2C=NC=CC=2)N1 |&1:2,13,26,28,30,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | Antimycobacterial, enoyl-ACP reductase inhibitor |
References
- K Maeda et al. A new antibiotic, pyridomycin. J Antibiot (Tokyo). 1953 Jul;6(3):140.
- H Ogawara et al. The chemistry of pyridomycin. Chem Pharm Bull (Tokyo). 1968 Apr;16(4):679-87.
- G Koyama et al. The structure of ryridomycin. Tetrahedron Lett. 1967 Sep;37:3587-90.
- RC Hartkoorn et al. Towards a new tuberculosis drug: pyridomycin - nature's isoniazid. EMBO Mol Med. 2012 Oct;4(10):1032-42.
- RC Hartkoorn et al. Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA. Nat Chem Biol. 2014 Feb;10(2):96-8.
