Piericidin A1
- AR 054 - Shaoguanmycin B - SN 198E
Axon N0038
CAS:
2738-64-9
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C25H37NO4
- MW: 415.57
Description
NADH:ubiquinone oxidoreductase inhibitor.******Source information: Streptomyces mobaraensisNADH:ubiquinone oxidoreductase inhibitorStreptomyces mobaraensis
More Information
| Parent CAS No. | 2738-64-9 |
|---|---|
| Chemical Name | 2-((2E,5E,7E,9R,10R,11E)-10-Hydroxy-3,7,9,11-tetramethyltrideca-2,5,7,11-tetraenyl)-5,6-dimethoxy-3-methylpyridin-4-ol |
| SMILES | C1(OC)C(O)=C(C)C(C/C=C(C)/C/C=C/C(/C)=C/[C@@H](C)[C@@H](O)/C(/C)=C/C)=NC=1OC |&1:18,20,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | NADH:ubiquinone oxidoreductase inhibitor |
References
- N Takahashi et al. Structure of Piercidin A.. J Am Chem Soc. 1965 May 5;87:2066-8.
- JG Okun et al. Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase). J Biol Chem. 1999 Jan 29;274(5):2625-30.
- N Ikezawa et al. Inhibition of photosystem II of spinach by the respiration inhibitors piericidin A and thenoyltrifluoroacetone. Biosci Biotechnol Biochem. 2002 Sep;66(9):1925-9.
- JH Hwang et al. Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator. J Cell Physiol. 2008 Apr;215(1):243-50.
- X Zhou X et al. The unique chemistry and biology of the piericidins. J Antibiot (Tokyo). 2016 Aug;69(8):582-93.
