Oxanosine
- NSC 359452
Axon N0037
CAS:
80394-72-5
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C10H12N4O6
- MW: 284.23
Description
Antitumor, inhibitor of GMP synthase and inosine mono phosphatase (IMP) dehydrogenase, inhibits HIV-1 replication.******Source information: Streptomyces capreolus MG265-CF3Antitumor, inhibitor of GMP synthase and inosine mono phosphatase (IMP) dehydrogenase, inhibits HIV-1 replicationStreptomyces capreolus MG265-CF3
More Information
| Parent CAS No. | 80394-72-5 |
|---|---|
| Chemical Name | 5-Amino-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)imidazo[4,5-d][1,3]oxazin-7(3H)-one |
| SMILES | O1C(=O)C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C=2N=C1N |&1:7,9,12,14,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | GMP synthase and IMP dehydrogenase inhibitor |
References
- N Shimada et al. Oxanosine, a novel nucleoside from actinomycetes. J Antibiot (Tokyo). 1981 Sep;34(9):1216-8.
- N Yagisawa et al. Mode of action of oxanosine, a novel nucleoside antibiotic. J Antibiot (Tokyo). 1982 Jun;35(6):755-9.
- M Nakamura et al. Synergistic anti-viral effect of oxanosine and ddI against human immunodeficiency virus. Biomed Pharmacother. 2005 Jan-Feb;59(1-2):47-50.
- Y Saito et al. Syntheses of oxanosine and carbocyclic oxanosine derivatives as anti-HIV agents. J Antibiot (Tokyo). 2000 Mar;53(3):309-13.
