Inostamycin A sodium salt
Axon N0029
- Parent CAS: 129905-10-8
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C38H67NaO11·
- MW: 722.92
Description
Antitumor.******Source information: Streptomyces sp. MH816-AF15AntitumorStreptomyces sp. MH816-AF15
More Information
| Parent CAS No. | 129905-10-8 |
|---|---|
| Chemical Name | Sodium (R)-2-((2R,3S,4R,5S,6R)-5-ethyl-6-((2S,3S,4S,6R)-6-((2S,2'R,3'R,4S,5S,5'R)-5'-ethyl-2'-hydroxy-5'-((S)-1-hydroxybutyl)-2,3',4-trimethyloctahydro-2,2'-bifuran-5-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-2,4-dihydroxy-3-methyltetrahydro-2H-pyran-2-yl)butanoate |
| SMILES | CC[C@@H](C([O-])=O)[C@@]1(O)[C@@H](C)[C@H](O)[C@H](CC)[C@]([C@@H](C)[C@H](O)[C@H](C)C(=O)[C@@H]([C@@]2([H])O[C@](C)([C@]3(O)O[C@]([C@H](CCC)O)(CC)C[C@H]3C)C[C@@H]2C)CC)([H])O1.[Na+] |&1:2,6,8,10,12,15,16,18,20,24,25,28,30,33,34,42,45,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | Active as antitumor |
References
- M Imoto et al. Isolation and structure determination of inostamycin, a novel inhibitor of phosphatidylinositol turnover. J. Nat. Prod. 1990, 53(4), 825-829).
- M Imoto et al. Inhibition of CDP-DG: inositol transferase by inostamycin. J Biochem. 1992 Aug;112(2):299-302.
- M Imoto et al. Inhibition of cyclin D1 expression and induction of apoptosis by inostamycin in small cell lung carcinoma cells. Jpn J Cancer Res. 1998 Mar;89(3):315-22.
- Y Baba et al. Inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, suppresses invasion ability by reducing productions of matrix metalloproteinase-2 and -9 and cell motility in HSC-4 tongue carcinoma cell line. Clin Exp Metastasis. 2000;18(3):273-9.
- Y Baba et al. Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines. Cell Biol Int. 2001;25(7):613-20.
- Huczyński A. Polyether ionophores-promising bioactive molecules for cancer therapy. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7002-10.
