Heparastatin hydrochloride
- SF4 hydrochloride
Axon N0027
- Parent CAS: 153758-25-9
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C8H11F3N2O5·HCl
- MW: 308.64
Description
Heparanase inhibitor
More Information
| Parent CAS No. | 153758-25-9 |
|---|---|
| Chemical Name | 4,5-Dihydroxy-6-(2,2,2-trifluoroacetamido)piperidine-3-carboxylic acid hydrochloride |
| SMILES | C1(O)C(C(O)=O)CNC(NC(=O)C(F)(F)F)C1O.Cl |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | Heparanase inhibitor |
References
- Y Nishimura et al.. Effect on spontaneous metastasis of mouse Lewis lung carcinoma by a trifluoroacetamide analogue of siastatin B. J Antibiot (Tokyo). 1994 Jul;47(7):840-2.
- Y Nishimura et al. Flexible synthesis and biological activity of uronic acid-type gem-diamine 1-N-iminosugars: a new family of glycosidase inhibitors. J Org Chem. 2000 Jan 14;65(1):2-11.
- M Sue et al. An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches. Int Immunopharmacol. 2016 Jun;35:15-21.
