Heliquinomycin
- NSC 702208 - Rubymycin
Axon N0026
CAS:
178182-49-5
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C33H30O17
- MW: 698.58
Description
DNA helicase inhibitor.******Source information: Streptomyces sp. MJ929-SF2DNA helicase inhibitorStreptomyces sp. MJ929-SF2
More Information
| Parent CAS No. | 178182-49-5 |
|---|---|
| Chemical Name | (2R,3R,3'R)-Methyl 3',4,9,10'-tetrahydroxy-3-(5-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yloxy)-7-methoxy-5,8,9'-trioxo-4',5,8,9'-tetrahydro-3H,3'H-spiro[naphtho[2,3-b]furan-2,2'-pyrano[4,3-g]chromene]-7'-carboxylate |
| SMILES | C1(OC)C(=O)C2C(O)=C3O[C@@]4(OC5C(O)=C6C(=O)OC(C(=O)OC)=CC6=CC=5C[C@H]4O)[C@H](OC4OC(C)C(O)C(OC)C4)C3=C(O)C=2C(=O)C=1 |&1:10,29,31,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | DNA helicase inhibitor |
References
- M Chino et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7.
- M Chino et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2. III. Biosynthesis. J Antibiot (Tokyo). 1997 Sep;50(9):781-4.
- M Chino et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6.
- T Sugiyama et al. Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase. J Biochem. 2012 Feb;151(2):129-37.
