Benastatin A
Axon N0007
CAS:
138968-85-1
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C30H28O7
- MW: 500.54
Description
Glutathione S-Transferase (GST) π class inhibitor, anti-MRSA.
Source information: Streptomyces sp. MI384-DF12
More Information
| Parent CAS No. | 138968-85-1 |
|---|---|
| Chemical Name | 1,7,9,11-tetrahydroxy-13,13-dimethyl-8-oxo-3-pentyl-8,13-dihydrobenzo[a]tetracene-2-carboxylic acid |
| SMILES | C1(O)C=C2C(C)(C)C3C=C4C5C(O)=C(C(=O)O)C(CCCCC)=CC=5C=CC4=C(O)C=3C(=O)C2=C(O)C=1 |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | GST π class inhibitor |
References
- T Aoyagi et al. Benastatins A and B, new inhibitors of glutathione S-transferase, produced by Streptomyces sp. MI384-DF12. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1992 Sep;45(9):1385-90.
- Z Xu et al. Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids. J Am Chem Soc. 2007 May 9;129(18):6022-30.
- I Kakizaki et al. Induction of apoptosis and cell cycle arrest in mouse colon 26 cells by benastatin A. Jpn J Cancer Res. 2000 Nov;91(11):1161-8.
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