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PTC 209
Axon 2420
CAS:
315704-66-6
Purity:
99%
- Soluble in DMSO
- MF: C17H13Br2N5OS
- MW: 495.19
Description
Inhibitor of the canonical self-renewal regulator BMI-1, a vital part of the polycomb repressive complex 1 (PRC1; IC50 value 0.5 µM for inhibition of UTR-mediated luciferase BMI-1 reporter expression). Treatment of primary colorectal cancer xenografts with PTC209 resulted in colorectal CIC loss with long-term and irreversible impairment of tumor growth. PTC-209 preferentially inhibits the proliferation of human lymphoma U937 and HT1080 tumor cells, and is less effective in primary human peripheral blood mononuclear cells and human hematopoietic stem cells.
More Information
| Parent CAS No. | 315704-66-6 |
|---|---|
| Chemical Name | N-(2,6-dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine |
| SMILES | S1C=C(C2N3C(=NC=2C)N=CC=C3)N=C1NC1=C(Br)C=C(OC)C=C1Br |
| MFCD | N.A. |
| InChi | InChI=1S/C17H13Br2N5OS/c1-9-15(24-5-3-4-20-16(24)21-9)13-8-26-17(22-13)23-14-11(18)6-10(25-2)7-12(14)19/h3-8H,1-2H3,(H,22,23) |
| InChiKey | XVOOCQSWCCRVDY-UHFFFAOYSA-N |
| CID | 1117196 |
| Short Description | BMI-1 inhibitor |
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