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ELN 484228
- NSC 164389
Axon 2382
CAS:
312-63-0
Purity:
99%
- Soluble in DMSO
- MF: C12H10FNO2S
- MW: 251.28
Description
α-Synuclein modulator with substantial biological activity in cellular models of α-synuclein-mediated dysfunction such as Parkinson’s Disease. ELN484228 reduced synaptic levels of αSyn in neuronal cultures from both wild type rats and from transgenic mice overexpressing αSyn by not more than two-fold, and ELN 484228 reversed αSyn-induced impairment of phagocytosis and protects dopaminergic neurons against the toxic effects of αSyn A53T over-expression.
More Information
| Parent CAS No. | 312-63-0 |
|---|---|
| Chemical Name | N-(4-fluorophenyl)benzenesulfonamide |
| SMILES | C1(S(NC2=CC=C(F)C=C2)(=O)=O)=CC=CC=C1 |
| MFCD | MFCD00091019 |
| InChi | InChI=1S/C12H10FNO2S/c13-10-6-8-11(9-7-10)14-17(15,16)12-4-2-1-3-5-12/h1-9,14H |
| InChiKey | AZORQGXJAXEIGC-UHFFFAOYSA-N |
| CID | 295229 |
| Short Description | α-Synuclein modulator |
