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TMDJ-035
- Ryanozole
Axon 4111
CAS:
2681302-83-8
Purity:
99%
- Soluble in DMSO
- MF: C16H12F3N5O
- MW: 347.29
Description
TMDJ-035 is a first highly potent and selective RyR2 inhibitor with an EC50 value of 0.013 μM. TMDJ-035 suppressed abnormal Ca2+ waves and transients in cardiomyocytes from a mouse model with RyR2(R420W) mutation. The inactive analog TMDJ-011 is available as Axon 4213.
More Information
| Parent CAS No. | 2681302-83-8 |
|---|---|
| Chemical Name | 2-(5-(3,5-Difluorophenyl)-2H-tetrazol-2-yl)-N-(4-fluorophenyl)-N-methylacetamide |
| MFCD | N.A. |
| Short Description | RyR2 inhibitor |
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