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DB2313 hydrochloride
Axon 3546
CAS:
2170606-74-1
Purity:
98%
- Soluble in DMSO
- MF: C42H41FN8O2
- MW: 708.83
Description
DB2313 hydrochloride is a potent inhibitor of the essential transcriptional factor PU.1 with an IC50 value of 14 nM.
More Information
| Parent CAS No. | 2170606-74-1 |
|---|---|
| Chemical Name | 2,2'-(4,4'-(2-Fluoro-1,3-phenylene)bis(methylene)bis(oxy)bis(4,1-phenylene))bis(N-isopropyl-1H-benzo[d]imidazole-6-carboximidamide) tetrahydrochloride |
| MFCD | N.A. |
| Short Description | PU.1 inhibitor |
References
- J Tu et al. PU.1 promotes development of rheumatoid arthritis via repressing FLT3 in macrophages and fibroblast-like synoviocytes. Ann Rheum Dis. 2023 Feb;82(2):198-211.
- I Antony-Debré et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017 Dec 1;127(12):4297-4313.
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