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Fludarabine
- 9-β-D-Arabinofuranosyl-2-fluoroadenine - F-ara-A
Axon 3457
CAS:
21679-14-1
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C10H12FN5O4
- MW: 285.23
Description
Fludarabine, a nucleoside analogue, inhibits DNA synthesis in proliferating cells; however, in indolent cells fludarabine has an inhibitory effect on RNA transcription. Additionally, Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation.
More Information
| Parent CAS No. | 21679-14-1 |
|---|---|
| Chemical Name | (2R,3S,4S,5R)-2-(6-Amino-2-fluoro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol |
| SMILES | [C@@H]1(O)[C@@H](CO)O[C@@H](N2C3N=C(F)N=C(N)C=3N=C2)[C@H]1O |&1:0,2,6,18,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C10H12FN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6+,9-/m1/s1 |
| InChiKey | HBUBKKRHXORPQB-FJFJXFQQSA-N |
| CID | 657237 |
| Short Description | DNA synthesis inhibitor |
References
- H Meng et al. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. Eur J Haematol. 2007 Dec;79(6):486-93.
- D Torella et al. Fludarabine prevents smooth muscle proliferation in vitro and neointimal hyperplasia in vivo through specific inhibition of STAT-1 activation. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2935-43.
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