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5-Bromo-2’-deoxyuridine
- BUdR - 5-BrdU - Broxuridine
Axon 3419
CAS:
59-14-3
- Optical Purity: Optically pure
- Soluble in water and DMSO
- MF: C9H11BrN2O5
- MW: 307.1
Description
Broxuridine is a nucleoside analog which is frequently used in analysis of neural stem cell biology, in particular to label and to fate-map dividing cells. Broxuridine is incorporated into newly synthesized DNA and has been shown to increase the susceptibility of incorporating cells to ionizing radiation. Moreover, Broxuridine inhibits cancer cell proliferation in vitro and in vivo.
More Information
| Parent CAS No. | 59-14-3 |
|---|---|
| Chemical Name | 5-Bromo-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione |
| SMILES | [C@@H]1(O)[C@@H](CO)O[C@@H](N2C=C(Br)C(=O)NC2=O)C1 |&1:0,2,6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1 |
| InChiKey | WOVKYSAHUYNSMH-RRKCRQDMSA-N |
| CID | 6035 |
| Short Description | Thymidine analog |
