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BC-DXI-843
Axon 3259
CAS:
2421117-98-6
- Optical Purity: 100% e.e.
- Soluble in DMSO
- MF: C28H26N4O4S2
- MW: 546.66
Description
BC-DXI-843 is a potent AIMP2-DX2 inhibitor (IC50 value of 0.92 μM) with more than 100-fold selectivity over AIMP2 in a luciferase assay. Moreover, BC-DXI-843 demonstrated in vivo efficacy in a tumor xenograft mouse model (H460 cells).
More Information
| Parent CAS No. | 2421117-98-6 |
|---|---|
| Chemical Name | (S)-3-(1H-Indol-3-yl)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-2-(4-methylphenylsulfonamido)propanamide |
| SMILES | C1(=CNC2C=CC=CC1=2)C[C@H](NS(=O)(=O)C1C=CC(C)=CC=1)C(=O)NC1SC=C(C2C=CC(OC)=CC=2)N=1 |&1:10,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C28H26N4O4S2/c1-18-7-13-22(14-8-18)38(34,35)32-25(15-20-16-29-24-6-4-3-5-23(20)24)27(33)31-28-30-26(17-37-28)19-9-11-21(36-2)12-10-19/h3-14,16-17,25,29,32H,15H2,1-2H3,(H,30,31,33)/t25-/m0/s1 |
| InChiKey | VLPGAOXBMXGNGM-VWLOTQADSA-N |
| CID | 146673132 |
| Short Description | AIMP2-DX2 inhibitor |
