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NFATc1 inhibitor A04
Axon 3909
CAS:
1912422-56-0
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C13H8F2INO2
- MW: 375.11
Description
NFATc1 inhibitor A04 is a potent inhibitor of RANKL-induced osteoclastogenesis and bone resorption, with an IC50 value of 1.57 μM and no significant cytotoxic effects on the viability of RAW264.7 cells. The anti-osteoclastogenic effects of A04 may operate through reducing the RANKL-induced nuclear translocation of NFATc1.
More Information
| Parent CAS No. | 1912422-56-0 |
|---|---|
| Chemical Name | 5-Fluoro-N-(2-fluoro-4-iodophenyl)-2-hydroxybenzamide |
| SMILES | C1(F)C=C(C(=O)NC2C=CC(I)=CC=2F)C(O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C13H8F2INO2/c14-7-1-4-12(18)9(5-7)13(19)17-11-3-2-8(16)6-10(11)15/h1-6,18H,(H,17,19) |
| InChiKey | IGRCFOGPIJEESA-UHFFFAOYSA-N |
| CID | 127043724 |
| Short Description | Osteoclastogenesis inhibitor |
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