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10 mg

$148.50

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50 mg

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ML 365

Name: ML 365
SKU: 2840

Axon 2840

CAS: 947914-18-3

Purity: 99%

Soluble in DMSO

MF: C22H20N2O3
MW: 360.41

Description

Potent and selective inhibitor of the TASK-1 (KCNK3) potassium channel (IC50 value of 4 nM) with 62-fold selectivity over TASK-3 in an orthogonal electrophysiology assay.

More Information

Certificate of Analysis (B1)

Material Safety Data Sheet (B1)

TASK-1

Parent CAS No.	947914-18-3
Chemical Name	2-Methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide
SMILES	C1(C)C=C(C(=O)NC2C=CC=C(NC(=O)C3C(OC)=CC=CC=3)C=2)C=CC=1
MFCD	N.A.
InChi	InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)
InChiKey	UTAJHKSGYJSZBR-UHFFFAOYSA-N
CID	46785920
Short Description	TASK-1 inhibitor

ML 365 TASK-1 inhibitor ML365 ML-365 CAS 947914-18-3 Axon Medchem Axon 2840 Potassium TASK-1 Inhibitor Ion Channels KCNK3 K2P3.1 Supplier Vendor

References

DP Flaherty et al. Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3968-73.

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